About the GPI

Mission, Objectives and Recommendations

Mission Statement

  • Raise the profile of pertussis as an important and preventable disease that warrants greater global public health attention.
  • Recommend effective immunization strategies for pertussis control.
  • Advocate for improved disease surveillance to optimize guidance on public policy and vaccine implementation strategies.

Goals and Objectives

  • Evaluate and communicate the need for improved pertussis control and for appropriate vaccination strategies.
  • Develop and communicate recommendations on pertussis immunization, disease surveillance, and strategies to control pertussis disease that are acceptable at national, regional, and local levels.
  • Advocate the importance of primary immunization and high DTP3 rates as the first target of any country implementing pertussis vaccination.
  • Systematically evaluate and prioritize strategies to address the status of pertussis worldwide and the rationale for immunization beyond childhood.
  • Improve understanding of the increasing incidence of reported pertussis.
  • Provide recommendations to help guide physicians in markets where both wP and aP vaccines are available.

Recommendations

  • Reinforce and/or improve current infant and toddler immunization strategies.
  • Those countries, particularly LMICs, using wP vaccines for primary infant and childhood immunization, should continue to do so and aim to achieve and/or maintain DTP3 coverage ≥90%.
  • Immunization of pregnant women should be a priority.
    • The GPI strongly recommends the use of aP vaccines in every pregnant woman where funding and supply make this feasible. Pregnant women should be a top priority group for receiving the aP vaccine.
  • Universal immunization of adolescents adults, where resources allow.
  • Immunization of healthcare and childcare workers, where resources allow.
  • Where national resources allow, aP vaccines should be given in all age groups because of their lower reactogenicity compared with wP vaccines.
  • Surveillance systems and diagnostic methods need to be improved:
    • The GPI recommends that, while culture remains the gold standard in identification of Bordetella pertussis, all countries should introduce PCR as a diagnostic method and, if possible, supplement with serology, where resources allow. Highest priority should be given to diagnose B. pertussis infections in hospitalized infants suspected to have pertussis.
    • The GPI advocates that the following clinical definitions should be used for the clinical diagnosis of pertussis (as per Cherry et al, CID, 2012):

    • Where wP vaccines are used, careful attention should be paid to quality control.